Silycap 140mg Capsule 30pcs Box
Silycap (Milk thistle) is indicated for the treatment and prevention of various liver conditions, including:
- Liver disease (both non-alcoholic & alcoholic)
- Liver cirrhosis (both non-alcoholic & alcoholic)
- Infectious hepatitis
- Drug-induced hepatitis
- Liver disease secondary to diabetes mellitus
- Toxicity of narcotics
- Fatty liver
- Jaundice
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Description:
The milk thistle, scientifically known as Silybum marianum (L.) Gaertn. (= Carduus marianus L.), belongs to the Asteraceae family (Fig. 1). This medicinal plant has a rich history dating back to the time of the birth of Christ. Its fruits, known as Fructus Cardui Mariae or seeds (Fig. 2), were traditionally used as an herbal remedy, and today they or their derivatives in effective dosages are recognized as therapeutic agents.
In 1968, Wagner et al. discovered a group of flavonoid compounds in the fruits of milk thistle, which were named silymarin. Further studies revealed that silymarin consists of three isomeric compounds: silibinin, silibinin, and silicristin, with a molecular formula of C25H22O10 and a molecular weight of 482.45 (Fig. 3).
The positive effects of silymarin on elevated serum enzyme levels, indicating parenchymal damage in patients with chronic liver diseases, have been evident in various nonblind controlled trials. Silymarin is indicated for toxic liver damage and supportive treatment in chronic inflammatory liver diseases and cirrhosis.
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Composition:
Each capsule contains a standardized extract of Milk thistle:
- 175 mg equivalent to Silymarin 140 mg
- 87.50 mg equivalent to Silymarin 70 mg
Pharmacology:
Silymarin, derived from Milk thistle, is a well-known hepatoprotective agent. It stimulates RNA polymerase-A, enhances protein synthesis, and aids in the regeneration and repair of liver cells. Its antioxidant properties are potent, protecting liver cells from damage caused by various toxins, infections, drugs, and pollutants. Silymarin also exhibits anti-inflammatory, membrane-stabilizing, immunomodulatory, and liver-regenerating effects.
Dosage & Administration:
Interaction:
Concomitant use of Silycap with butyrophenones or phenothiazines may reduce lipid peroxidation.
Contraindications:
- Contraindicated in patients with known hypersensitivity to silymarin.
Side Effects:
Well tolerated in recommended doses. Occasionally, mild laxative effects may be observed.
Pregnancy & Lactation:
No sufficient data are available regarding the use of Silymarin during pregnancy and lactation. Caution is advised, and usage should be determined by a physician.
Storage Conditions:
Store in a cool, dry place, away from light and moisture. Keep out of reach of children.
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